HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-Isopropylamino-pyrazole-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Acetone | HCID 180 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | tert-Butyl 3-amino-1H-pyrazole-1-carboxylate | HCID 51358380 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Isopropylamino-pyrazole-1-carboxylic acid tert-butyl ester | HCID 57942276 | — |
Reaction Steps
A mixture of acetone (0.1 mL, 1.4 mmol), acetic acid (0.078 mL, 1.43 mmol) and 3-amino-pyrazole-1-carboxylic acid tert-butyl ester (200 mg, 1.1 mmol) in DCM (5 mL) was stirred at RT for 1 hour. Sodium triacetoxyborohydride (467 mg, 2.2 mmol) was added and the mixture stirred overnight. The mixture was extracted with ethyl acetate, washed with water, dried and concentrated. The residue was purified by flash column to give 3-Isopropylamino-pyrazole-1-carboxylic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093247B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-e4d6b325412d41cc8f96a079b12477d2 |
| Source note | uspto-grants-2012_01 |