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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 419188Generated: October 30, 2026

3-({5-Chloro-3-[(4-chloro-3-trifluoromethyl-benzenesulfonyl)-methoxymethyl-amino]-pyridine-2-carbonyl}-isopropyl-amino)-pyrazole-1-carboxylic acid tert-butyl ester → HCID 178457751, compound

https://huagongshe.com/reaction/419188

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-({5-Chloro-3-[(4-chloro-3-trifluoromethyl-benzenesulfonyl)-methoxymethyl-amino]-pyridine-2-carbonyl}-isopropyl-amino)-pyrazole-1-carboxylic acid tert-butyl esterHCID 57942189—
SolventHydrochloric AcidHCID 313—
SolventWaterHCID 962—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 178457751HCID 178457751—

Reaction Conditions

Temperature85 °C

Reaction Steps

3-({5-chloro-3-[(4-chloro-3-trifluoromethyl-benzenesulfonyl)-methoxymethyl-amino]-pyridine-2-carbonyl}-isopropyl-amino)-pyrazole-1-carboxylic acid tert-butyl ester from step 2 was dissolved in a mixture of 4 M HCl in dioxane (4 mL) and water (1 mL), heated to 85° C. for 2 h. The solvent was evaporated and the residue was purified with HPLC to give 5-chloro-3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyridine-2-carboxylic acid isopropyl-(1H-pyrazol-3-yl)-amide. MS m/z: 522 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08093247B2
Source datasetuspto-grants-2012_01
ORD IDord-f993fed5d85a448dadd9b42a408be839
Source noteuspto-grants-2012_01