HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 419196Generated: October 25, 2026
Morpholine → N-methoxy-N-methyl-2-morpholin-4-yl-isonicotinamide
https://huagongshe.com/reaction/419196
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-Chloro-N-methoxy-N-methylisonicotinamide | HCID 18506894 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | 1,4-Naphthoquinone palladium(0) | HCID 86610779 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-methoxy-N-methyl-2-morpholin-4-yl-isonicotinamide | HCID 57942148 | — |
Reaction Steps
A mixture of 2-chloro-N-methoxy-N-methyl-isonicotinamide (800 mg, 4 mmol), morpholine (452 mg, 5.2 mmol), sodium tert-butoxide (500 mg, 5.2 mmol), 1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidene(1,4-naphthoquinone palladium(0) dimer in dioxane (4 mL) was stirred at 80° C. overnight. The mixture was diluted with ethyl acetate, washed with water and purified by flash column to give N-methoxy-N-methyl-2-morpholin-4-yl-isonicotinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093247B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-000824a19cd44d92ad5c1154a859c18f |
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| Source note | uspto-grants-2012_01 |
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