反应详情

温度

125 °C

A mixture of 7-benzyloxyquinolin-4-ol (71.47 g, 0.2844 mol) and propionic acid (700 mL) was heated to 125° C. with vigorous stirring. Nitric acid (23.11 mL of 16 molar (M)) was slowly added over a period of 30 minutes while maintaining the reaction temperature between 121° C. and 125° C. After the addition, the reaction was stirred at 125° C. for 1 hour then allowed to cool to ambient temperature. The resulting solid was isolated by filtration, washed with water, and dried in an oven for 1.5 days to provide 69.13 g of 7-benzyloxy-3-nitroquinolin-4-ol as a grayish powder.

1. temperaturewhile maintaining the reaction temperature between 121° C. and 125° C
2. additionAfter the addition
3. temperatureto cool to ambient temperature
4. customThe resulting solid was isolated by filtration
5. washwashed with water
6. customdried in an oven for 1.5 days