HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-[(2-methyl-3-nitrophenyl)methyl]piperazine → 2-Methyl-3-((4-methylpiperazin-1-yl)methyl)benzeneamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-[(2-methyl-3-nitrophenyl)methyl]piperazine | HCID 59427904 | — |
| Reactant | 2-Methoxy-4-[4-(1-piperidyl)-1-piperidyl]aniline | HCID 59712087 | — |
| Product | 2-Methyl-3-((4-methylpiperazin-1-yl)methyl)benzeneamine | HCID 28721681 | — |
Reaction Steps
The title compound of step B was prepared from 1-methyl-4-[(2-methyl-3-nitrophenyl)methyl]-piperazine in an analogous manner as that described for the synthesis of 4-(1,4′-bipiperidin-1′-yl)-2-(methyloxy)aniline (Example 22, step C). 1H NMR (400 MHz, DMSO-d6) δ 6.52 (d, J=6.8 Hz, 1H), 6.53 (d, J=6.8 Hz, 1H), 6.40 (d, J=7.5 Hz, 1H), 4.69 (s, 2H), 3.28 (s, 2H), 2.14-2.40 (m, 8H), 2.11 (s, 3H), 1.99 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093239B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-bd7a7a6c3f7a4abe86e9db37c40a56d4 |
| Source note | uspto-grants-2012_01 |