反应详情

Acetophenone 12 (30 mg, 0.181 mmol) was condensed with O-(4-cyanobenzyl)hydroxylamine hydrochloride (35) (37 mg, 0.200 mmol) according to the general procedure II-B defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The ensuing solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30283 (27 mg, 51%) as a white solid, m.p. 125.9-129.7° C.

1. temperatureAfter being heated for 3 h the reaction mixture
2. temperaturewas cooled
3. customthe solvent removed under reduced pressure
4. filtrationThe ensuing solid was filtered off
5. washwashed with cold isopropanol (3.0 mL)