HCID 59453009, compound → HCID 59452872, compound

Participants

Reaction Steps

To (9aS)-8-{1-[3-(methyloxy)-4-nitrophenyl]-4-piperidinyl}octahydropyrazino[2,1-c][1,4]-oxazine (0.516 g, 1.35 mmol) in EtOAc (50 mL) was added Pd on carbon. The mixture was stirred under H2 (1 atm) overnight. The mixture was filtered through Celite® to provide the title compound of step I (0.417 g, 1.20 mmol, 89%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.44-1.56 (m, 2H), 1.77-1.88 (m, 2H), 2.10-2.22 (m, 2H), 2.42 (s, 4H), 2.48 (s, 5H), 2.58 (d, J=12.1 Hz, 1H), 2.69 (d, J=9.9 Hz, 1H), 3.04 (t, J=10.4 Hz, 1H), 3.37-3.47 (m, 3H), 3.59 (d, J=11.4 Hz, 1H), 3.66-3.73 (m, 5H), 6.25 (dd, J=8.3, 2.1 Hz, 1H), 6.43-6.51 (m, 2H).

Provenance & Evidence