Hydrochloride methanol → Hydrochloric Acid

https://huagongshe.com/reaction/419501

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloride methanol	HCID 21893726	—
Reactant	tert-Butyl 4-(2-(methylsulfonyl)ethyl)piperazine-1-carboxylate	HCID 66649624	—
Solvent	Methanol	HCID 887	—
Product	Hydrochloric Acid	HCID 313	688%
Product	1-[2-(Methylsulfonyl)ethyl]piperazine hydrochloride	HCID 66649667	—

Reaction Conditions

Temperature	50 °C

Reaction Steps

To the solution of 1,1-dimethylethyl 4-[2-(methylsulfonyl)ethyl]-1-piperazinecarboxylate (106 g, 360 mmol) in MeOH (500 mL) was added HCl/MeOH (5M, 1000 mL, 5000 mmol), and the mixture was heated at 50° C. for 1 h before evaporating most of the solvent. The residue was filtered and washed with MeOH to give the desired product as HCl salt (90.3 g, 95% yield). 1H NMR (400 MHz, D2O) δ ppm 3.30-3.72 (m, 12H), 3.09 (s, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093239B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-150cedc1236e4aa0b64fff3c19bc21f0
Source note	uspto-grants-2012_01