HCID 59452860, compound → HCID 59452583, compound

Participants

Reaction Steps

The title compound of step D (0.249 g, 0.770 mmol, 74%) was prepared from 1-[2-(methylsulfonyl)ethyl]-4-(4-nitro-3-propylphenyl)-1,2,3,6-tetrahydropyridine in an analogous manner to that of 4-{4-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-1-piperidinyl}-2-(methyloxy)aniline (Example 87, step I). 1H NMR (400 MHz, CDCl3) δ ppm 1.00 (t, J=7.3 Hz, 3H), 1.61-1.71 (m, 4H), 1.83 (d, J=14.3 Hz, 2H), 2.14 (td, J=11.7, 2.2 Hz, 2H), 2.38 (dt, J=12.0, 3.7 Hz, 1H), 2.41-2.47 (m, 2H), 2.89 (t, J=6.4 Hz, 2H), 3.01 (d, J=11.4 Hz, 2H), 3.06 (s, 3H), 3.17 (t, J=6.4 Hz, 2H), 3.54 (br. s., 2H), 6.60-6.64 (m, 1H), 6.85-6.89 (m, 2H).

Provenance & Evidence