Potassium Carbonate → HCID 86625198, compound

Participants

Reaction Steps

To N-[2-(ethyloxy)-4-(4-piperidinyl)phenyl]-2,2,2-trifluoroacetamide acetate (2.2 g, 5.9 mmol) and methyl vinyl sulfone (0.74 g, 7.0 mmol) in DCM (50 mL) was added K2CO3 (1.2 g, 8.8 mmol). A few drops of MeOH were added to help solubilize the reagents. The reaction was stirred in a sealed tube three h. The reaction was filtered then purified by silica gel chromatography. The desired fractions were combined, and the solvent was removed under vacuum to provide the title compound of step F as a white solid (1.4 g, 3.3 mmol, 58%). 1H NMR (400 MHz, DMSO-d6) δ 8.52 (br s, 1H), 8.18 (d, J=8.2 Hz, 1H), 6.81 (dd, J=8.2, 1.6 Hz, 1H), 6.73 (d, J=1.6 Hz, 1H), 4.11 (q, J=7.0 Hz, 2H), 3.15 (t, J=6.6 Hz, 2H), 3.02 (s, 3H), 3.00 (d, J=11.7 Hz, 2H), 2.88 (t, J=6.6 Hz, 2H), 2.52-2.42 (m, 1H), 2.18-2.10 (m, 2H), 1.84 (d, J=12.8 Hz, 2H), 1.73-1.60 (m, 2H), 1.44 (t, J=7.0 Hz, 3H).

Provenance & Evidence