HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 41962Generated: October 26, 2026
Sodium Hydroxide → 2-Amino-1,2,3,4-tetrahydro-1,4-phthalazinedione sodium salt
https://huagongshe.com/reaction/41962
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Nitrophthalic anhydride | HCID 21631 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 3-Aminobenzene-1,2-dicarbohydrazide | HCID 245521 | — |
| Reactant | 2-Aminophthalohydrazide | HCID 66811964 | — |
| Reactant | 2-Nitrophthalic hydrazide | HCID 87227270 | — |
| Reactant | 2-Amino-1,2,3,4-tetrahydrophthalazine-1,4-dione sodium salt dihydrate | HCID 131730842 | — |
| Catalyst | Nickel aluminide | HCID 6336846 | — |
| Product | 2-Amino-1,2,3,4-tetrahydro-1,4-phthalazinedione sodium salt | HCID 66990329 | — |
Reaction Steps
In the patent RU 2138264, there is described a method for obtaining compound III, that is 2-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione sodium salt dihydrate and it includes transformation of 3-nitrophtalic acid anhydride by means of hydrazine hydrate into 2-nitrophthalic hydrazide which is transformed into 3-aminophthalohydrazide by means of hydrazine hydrate in alkaline medium at presence of nickel-aluminum alloy, thereafter there is performed molecular rearrangement to 2-aminophthalohydrazide by means of bromine under pressure. In the final stage there are mixed 2-amino-phthalohydrazide and NaOH solution at the temperature up to 85° C. thereafter the mixture is filtered and evaporated up to obtaining 2-amino-1,2,3,4-tetrahydro-1,4-phthalazinedione sodium salt dehydrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536171B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-403c782a2017465b8f1201570a76b30c |
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| Source note | uspto-grants-2013_09 |
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