HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1-Benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-Benzylpiperidine-4-carbonitrile hydrochloride | HCID 66650234 | — |
| Product | 1-Benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride | HCID 66650058 | 113% |
Reaction Steps
Dissolve 1-Benzyl-piperidine-4-carbonitrile hydrochloride (1.00 equiv; 57.3 mmoles; 13.57 g) in 75 mL MeOH and cool in ice bath. Saturate with HCl gas for 25 minutes, then remove ice bath and stir for 3 hours. Evaporate under reduced pressure to give 17.47 g (65.0 mmol, 113%) 1-benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093383B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-71e51212e9114125b3b6a0d3e8132c5c |
| Source note | uspto-grants-2012_01 |