Ammonium formate → HCID 66649874, compound

Participants

Reaction Steps

Combine 1-Benzyl-4-[5-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperazine (260 mg, 1.00 equiv; 0.643 mmoles), 20 wt % Pd(OH)2/C Degussa E101NE/W (250 mg); methanol (10 mL), formic acid, ammonium salt (20 equiv, 12.8 mmoles; 810 mg) and heated to 50° C. for 2 hours, then cooled to room temperature. Filter the reaction mixture through Celite®, evaporate under reduced pressure and coevaporate once with methanol to give 195.2 mg (0.621 mmol, 97%) 1-[5-(4-Fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperazine as a yellow foam.

Provenance & Evidence