Water → HCID 66651303, compound

Participants

Reaction Steps

A mixture of EXAMPLE 1D (0.8 g) in polyphosphoric acid (8 mL) was stirred at 100° C. for 3 hours. The mixture was cooled, treated with water and extracted with dichloromethane. The solid that precipitated out of the organic layer was filtered, washed with water and dried to afford the title compound. 1H NMR (DMSO-d6) δ 9.24 (s, 1H), 8.33 (d, J=7.9 Hz, 1H), 8.18-8.21 (m, 1H), 8.11-8.14 (m, 2H), 7.94 (s, 1H), 7.56 (t, J=7.9 Hz, 1H), 7.15-7.19 (m, 2H), 3.89 (s, 3H).

Provenance & Evidence