HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → (S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 18604408 | HCID 18604408 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate | HCID 86643491 | — |
Reaction Steps
A solution of (S)-1-(benzyloxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid (1.50 g) in dichloromethane (30 mL) was treated with oxalyl chloride (0.65 mL) and 3 drops of N,N-dimethylformamide at ambient temperature for 1.5 hours. The mixture was concentrated and the crude material used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093396B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-377d50e1d6664017ba4a218ebd63499c |
| Source note | uspto-grants-2012_01 |