反应详情

A solution of 0.354 g (3.34 mM) of sodium carbonate in 3 ml of water, 0.18 g (0.223 mM) of the [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane and 0.68 g (4.46 mM) of 2-methoxy-3-pyridineboronic acid are added to a solution of 1 g (2.23 mM) of 6-bromo-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside, obtained according to preparation IV, in 10 ml of DME. The reaction mixture is heated using microwave radiation at 120° C. for 20 minutes and cooled, water is added and extraction is carried out with ethyl acetate. The organic phase is washed with a 1M sodium carbonate solution and then with water to neutral pH, dried over magnesium sulfate and concentrated under reduced pressure. The evaporation residue is purified by chromatography on a silica column (eluent: toluene/acctone 90/10; v/v) in order to obtain the expected product in the form of a white solid with a yield of 70%.

1. customobtained
2. temperatureThe reaction mixture is heated
3. customat 120° C.
4. customfor 20 minutes
5. temperaturecooled
6. extractionextraction
7. washThe organic phase is washed with a 1M sodium carbonate solution
8. dry with materialwith water to neutral pH, dried over magnesium sulfate
9. concentrationconcentrated under reduced pressure
10. customThe evaporation residue is purified by chromatography on a silica column (eluent: toluene/acctone 90/10; v/v) in order