(Pyridin-4-yl)boronic acid → HCID 66650852, compound

HRID 419794Notes

Reaction equation

HRID 419794 reaction equation
[C:1]([O:4][C@@H:5]1[C@@H:19]([O:20][C:21](=[O:23])[CH3:22])[C@H:18]([O:24][C:25](=[O:27])[CH3:26])[CH2:17][S:16][C@H:6]1[O:7][C:8]1[C:9]([F:15])=[N:10][CH:11]=[C:12](Br)[CH:13]=1)(=[O:3])[CH3:2].[N:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1>>[C:1]([O:4][C@@H:5]1[C@@H:19]([O:20][C:21](=[O:23])[CH3:22])[C@H:18]([O:24][C:25](=[O:27])[CH3:26])[CH2:17][S:16][C@H:6]1[O:7][C:8]1[C:9]([F:15])=[N:10][CH:11]=[C:12]([C:31]2[CH:32]=[CH:33][N:28]=[CH:29][CH:30]=2)[CH:13]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 66651049HCID 66651049, compound

Product 1

HCID 66650852HCID 66650852, compound

Procedure

By carrying out the operation analogously to example 1, starting from 5-bromo-2-fluoro-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside, obtained according to preparation VIII, and 4-pyridineboronic acid, the desired product is obtained in the form of a beige foam (yield=53%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-05632a4c4ed74e39b5f3916955c5b5b3
Source dataset
uspto-grants-2012_01
Patent number
US08093394B2

Reaction notes

Loading…