(Pyridin-4-yl)boronic acid → HCID 66651287, compound

HRID 419815Notes

Reaction equation

HRID 419815 reaction equation
[C:1]([O:4][C@@H:5]1[C@@H:18]([O:19][C:20](=[O:22])[CH3:21])[C@H:17]([O:23][C:24](=[O:26])[CH3:25])[CH2:16][S:15][C@H:6]1[O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10](Br)[CH:9]=1)(=[O:3])[CH3:2].[N:27]1[CH:32]=[CH:31][C:30](B(O)O)=[CH:29][CH:28]=1>>[C:1]([O:4][C@@H:5]1[C@@H:18]([O:19][C:20](=[O:22])[CH3:21])[C@H:17]([O:23][C:24](=[O:26])[CH3:25])[CH2:16][S:15][C@H:6]1[O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([C:30]2[CH:31]=[CH:32][N:27]=[CH:28][CH:29]=2)[CH:9]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 86625028HCID 86625028, compound

Product 1

HCID 66651287HCID 66651287, compound

Procedure

By carrying out the operation analogously to example 1, starting from 2-bromo-4-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside, obtained according to preparation VII, and 4-pyridineboronic acid, the desired product is obtained in the form of a white solid (yield=53%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-dc0a8b2b43f34797951b9cf36ecf58c1
Source dataset
uspto-grants-2012_01
Patent number
US08093394B2

Reaction notes

Loading…