3-Bromo-5-methylpyridine → HCID 66651031, compound

HRID 419816Notes

Reaction equation

HRID 419816 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:9]([O:12][C@@H:13]1[C@@H:26]([O:27][C:28](=[O:30])[CH3:29])[C@H:25]([O:31][C:32](=[O:34])[CH3:33])[CH2:24][S:23][C@H:14]1[O:15][C:16]1[CH:17]=[N:18][C:19](Br)=[CH:20][CH:21]=1)(=[O:11])[CH3:10]>>[C:9]([O:12][C@@H:13]1[C@@H:26]([O:27][C:28](=[O:30])[CH3:29])[C@H:25]([O:31][C:32](=[O:34])[CH3:33])[CH2:24][S:23][C@H:14]1[O:15][C:16]1[CH:17]=[N:18][C:19]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=2)=[CH:20][CH:21]=1)(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 8177133-Bromo-5-methylpyridineHCID 86625029HCID 86625029, compound

Product 1

HCID 66651031HCID 66651031, compound

Procedure

By carrying out the operation analogously to example 137, starting from 3-bromo-5-methylpyridine and 6-bromo-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside, obtained according to preparation IV, the desired product is obtained in the form of a white solid (yield=38%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-ea01947ee608442c8ffd98e6e7bf4dc4
Source dataset
uspto-grants-2012_01
Patent number
US08093394B2

Reaction notes

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