3-Bromo-5-methoxypyridine → HCID 66651455, compound

HRID 419817Notes

Reaction equation

HRID 419817 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.[C:10]([O:13][C@@H:14]1[C@@H:27]([O:28][C:29](=[O:31])[CH3:30])[C@H:26]([O:32][C:33](=[O:35])[CH3:34])[CH2:25][S:24][C@H:15]1[O:16][C:17]1[CH:18]=[N:19][C:20](Br)=[CH:21][CH:22]=1)(=[O:12])[CH3:11]>>[C:10]([O:13][C@@H:14]1[C@@H:27]([O:28][C:29](=[O:31])[CH3:30])[C@H:26]([O:32][C:33](=[O:35])[CH3:34])[CH2:25][S:24][C@H:15]1[O:16][C:17]1[CH:18]=[N:19][C:20]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH3:9])[CH:7]=2)=[CH:21][CH:22]=1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 8171633-Bromo-5-methoxypyridineHCID 86625029HCID 86625029, compound

Product 1

HCID 66651455HCID 66651455, compound

Procedure

By carrying out the operation analogously to example 137, starting from 3-bromo-5-methoxypyridine and 6-bromo-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside, obtained according to preparation IV, the desired product is obtained in the form of a white solid (yield=48%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-2194bd487b9f447f8393176000dd5ea5
Source dataset
uspto-grants-2012_01
Patent number
US08093394B2

Reaction notes

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