(6-Fluoropyridin-3-yl)boronic acid → HCID 66651462, compound

HRID 419824Notes

Reaction equation

HRID 419824 reaction equation
C([O:4][C@@H:5]1[C@@H:18]([O:19]C(=O)C)[C@H:17]([O:23]C(=O)C)[CH2:16][S:15][C@H:6]1[O:7][C:8]1[C:9](Br)=[N:10][CH:11]=[CH:12][CH:13]=1)(=O)C.[F:27][C:28]1[N:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1>>[O:7]([C:8]1[C:9]([C:31]2[CH:32]=[N:33][C:28]([F:27])=[CH:29][CH:30]=2)=[N:10][CH:11]=[CH:12][CH:13]=1)[C@@H:6]1[S:15][CH2:16][C@@H:17]([OH:23])[C@H:18]([OH:19])[C@H:5]1[OH:4]

Participants

3

Reactant 2

HCID 2783397(6-Fluoropyridin-3-yl)boronic acidHCID 12136256HCID 12136256, compound

Product 1

HCID 66651462HCID 66651462, compound

Procedure

By carrying out the operation analogously to example 239, starting from 2-bromo-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside, obtained according to preparation III, and 6-fluoro-3-pyridineboronic acid, the desired product is obtained in the form of a white powder (yield=14%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-d1a2ea10043240a1b8390c8629e362aa
Source dataset
uspto-grants-2012_01
Patent number
US08093394B2

Reaction notes

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