1,1-Dimethylethyl 4-[[6-(2-aminophenyl)imidazo[2,1-b]thiazol-3-yl]methyl]-1-piperazinecarboxylate → HCID 25232896, compound

HRID 419872Notes

Reaction equation

HRID 419872 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11](CC2N3C=C(C4C=CC=CC=4N)N=C3SC=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N+:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[C:39]1[N:40]=[C:41]2[N:45]([CH:46]=1)[CH:44]=[C:43]([CH2:47]O)[S:42]2)([O-])=O>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:47][C:43]2[S:42][C:41]3=[N:40][C:39]([C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=4[NH2:30])=[CH:46][N:45]3[CH:44]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 252327051,1-Dimethylethyl 4-[[6-(2-aminophenyl)imidazo[2,1-b]thiazol-3-yl]methyl]-1-piperazinecarboxylateHCID 25232894HCID 25232894, compound

Product 1

HCID 25232896HCID 25232896, compound

Procedure

Essentially the same procedure used during the preparation of 4-[6-(2-amino-phenyl)-imidazo [2,1-b]thiazol-3-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester was employed, except that [6-(2-nitro-phenyl)-imidazo[2,1-b]thiazol-2-yl]-methanol was used as the starting material.

Sources & evidence

ORD record
ord-bd794f14c904418f9b0e098e5ddb8de6
Source dataset
uspto-grants-2012_01
Patent number
US08093401B2

Reaction notes

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