HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 419884Generated: October 26, 2026
Phosphorus sulfide (P2S5) → 2-(4-Nitrophenyl)thiazolo[4,5-c]pyridine
https://huagongshe.com/reaction/419884
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | HCID 178522384 | HCID 178522384 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | P-Xylene | HCID 7809 | — |
| Product | 2-(4-Nitrophenyl)thiazolo[4,5-c]pyridine | HCID 21770648 | 59% |
Reaction Steps
A mixture of N-(4-hydroxypyridin-3-yl)-4-nitrobenzamide (5.18 g, 0.02 mol) and P2S5 (8.90 g, 0.04 mol) in pyridine (25 mL) and p-xylene (100 mL) was stirred at 140° C. for 18 h. The solvent was removed under vacuo while hot and the residue was purified by recrystallization from EtOH to afford 2-(4-nitrophenyl)thiazolo[4,5-c]pyridine as a yellow solid (3.00 g, yield: 59%). MS (ESI), calcd for C12H7N3O2S (m/z): 257, found: 258 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08093401B2 |
|---|
| Source dataset | uspto-grants-2012_01 |
|---|
| ORD ID | ord-814ae81ae8654ca5a3208785672f7b16 |
|---|
| Source note | uspto-grants-2012_01 |
|---|
