HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(2-Hydroxyethyl)amino]-3-nitrobenzonitrile → 3-Amino-2-[(2-hydroxyethyl)amino]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(2-Hydroxyethyl)amino]-3-nitrobenzonitrile | HCID 11447095 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-2-[(2-hydroxyethyl)amino]benzonitrile | HCID 58298498 | 106.3% |
Reaction Steps
Methanol (500 ml) and Pd/activated charcoal 5% (wet, 3.45 g) are added to 2-[(2-hydroxyethyl)amino]-3-nitrobenzonitrile (69 g, 0.333 mol). The suspension is shaken in a Parr apparatus under 20 psi pressure of hydrogen for 1 hour. The mixture is then filtered on Celite and evaporated to dryness to give the desired material (62.7 g). This product is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093402B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-1e16d104712e47599c2f1eab463aeca0 |
| Source note | uspto-grants-2012_01 |