HuagongsheHuagongshe Chemistry Print Report · For research reference only
(7-Cyano-1H-benzimidazol-1-yl)acetic acid → (7-acetyl-1H-benzimidazol-1-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (7-Cyano-1H-benzimidazol-1-yl)acetic acid | HCID 11195002 | — |
| Reactant | 1-[1-(2-Hydroxyethyl)-1H-benzimidazol-7-yl]ethanone | HCID 58298500 | — |
| Product | (7-acetyl-1H-benzimidazol-1-yl)acetic acid | HCID 58298480 | 75% |
Reaction Steps
1-[1-(2-Hydroxyethyl)-1H-benzimidazol-7-yl]ethanone (0.30 g, 1.47 mmol) is oxidized to the desired acid according to the procedure described for the synthesis of (7-Cyano-1H-benzimidazol-1-yl)acetic acid (step f, intermediate 14) to give the desired product (0.24 g, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093402B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-6f2ce421be4344afb8400d3c7f0a2dfe |
| Source note | uspto-grants-2012_01 |