反应详情

2,3-Difluoronitrobenzene (15 g, 94.3 mmol) is dissolved in 200 mL of ethanol. Ethanolamine (11.4 ml, 188.7 mmol, 2 equiv) is added and the mixture stirred at room temperature overnight (reaction complete by TLC). Ethanol is evaporated and the resulting residue is dissolved in ethyl acetate, washed with water (to eliminate excess ethanolamine), dried over magnesium sulphate, filtered and evaporated to dryness, giving the desired product as a deep orange oil (18.3 g, 97%). This crude material was used for the next step without further purification.

1. custom(reaction complete by TLC)
2. customEthanol is evaporated
3. dissolutionthe resulting residue is dissolved in ethyl acetate
4. washwashed with water (to eliminate excess ethanolamine)
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. customevaporated to dryness