3-Chloro-4-methoxyaniline → 1-(2-Amino-4-chloro-5-methoxyphenyl)ethanone

HRID 420035Notes

Reaction equation

HRID 420035 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[NH2:5].NC1C=[C:16]([O:18]C)[CH:15]=CC=1C(=O)C>>[NH2:5][C:4]1[CH:3]=[C:2]([Cl:1])[C:8]([O:9][CH3:10])=[CH:7][C:6]=1[C:16](=[O:18])[CH3:15]

Participants

3

Reactant 2

HCID 214413-Chloro-4-methoxyanilineHCID 106786151-(2-Amino-4-methoxyphenyl)ethan-1-one

Product 1

HCID 666504821-(2-Amino-4-chloro-5-methoxyphenyl)ethanoneYield 50%

Procedure

Compound 40g was synthesized from 3-chlor-4-methoxy-aniline 39g as a brown solid in 50% yield, according to the procedure as described for compound 40a.

Sources & evidence

ORD record
ord-b9516426a4584268bf3dcd01ee50363f
Source dataset
uspto-grants-2012_01
Patent number
US08093379B2

Reaction notes

Loading…