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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420036Generated: October 30, 2026

N-(2-acetyl-5-methoxyphenyl)-4-Isopropyl-2-Thiazolecarboxamide → N-(6-acetyl-2-fluoro-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide

https://huagongshe.com/reaction/420036

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-acetyl-5-methoxyphenyl)-4-Isopropyl-2-ThiazolecarboxamideHCID 20773655—
Reactant1-(2-Amino-3-fluoro-4-methoxyphenyl)ethanoneHCID 44203147—
Reactant4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chlorideHCID 57578796—
ProductN-(6-acetyl-2-fluoro-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamideHCID 6665049484%

Reaction Steps

Compound 42c was synthesized from 1-(2-amino-3-fluoro-4-methoxyphenyl)ethanone and compound 38 as a beige solid in 84% yield, according to the procedure as described for compound 42a.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08093379B2
Source datasetuspto-grants-2012_01
ORD IDord-ea2966bb62134f948c5383ac1c1ce338
Source noteuspto-grants-2012_01