N-(2-acetyl-3,5-dimethoxy-phenyl)-4-isopropylthiazole-2-carboxamide → 2-(4-Isopropylthiazol-2-yl)-5,7-dimethoxyquinolin-4-ol

HRID 420043Notes

Reaction equation

HRID 420043 reaction equation
[C:1]([C:4]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([O:12][CH3:13])=[CH:6][C:5]=1[NH:14][C:15]([C:17]1[S:18][CH:19]=[C:20]([CH:22]([CH3:24])[CH3:23])[N:21]=1)=O)(=[O:3])[CH3:2].C(C1N=C(C2C=C(O)C3C(=CC(OC)=CC=3)N=2)SC=1)(C)C>>[CH:22]([C:20]1[N:21]=[C:17]([C:15]2[CH:2]=[C:1]([OH:3])[C:4]3[C:5](=[CH:6][C:7]([O:12][CH3:13])=[CH:8][C:9]=3[O:10][CH3:11])[N:14]=2)[S:18][CH:19]=1)([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 66650681N-(2-acetyl-3,5-dimethoxy-phenyl)-4-isopropylthiazole-2-carboxamideHCID 178487691HCID 178487691, compound

Product 1

HCID 1784933972-(4-Isopropylthiazol-2-yl)-5,7-dimethoxyquinolin-4-olYield 60%

Procedure

Compound 43e was synthesized from compound 42e as a yellow solid in 60% yield, according to the procedures as described for compound 43a.

Sources & evidence

ORD record
ord-309e46a37b8b45a9a6ded640c888820b
Source dataset
uspto-grants-2012_01
Patent number
US08093379B2

Reaction notes

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