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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420049Generated: October 29, 2026

4-(Trifluoromethyl)thiazole-2-carboxylic acid → N-(6-acetyl-3-methoxy-2-methylphenyl)-4-(trifluoromethyl)-1,3-thiazole-2-carboxamide

https://huagongshe.com/reaction/420049

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)thiazole-2-carboxylic acidHCID 18673010—
ReactantN-(2-acetyl-5-methoxyphenyl)-4-Isopropyl-2-ThiazolecarboxamideHCID 20773655—
Reactant2'-Amino-3'-methyl-4'-methoxyacetophenoneHCID 25067316—
ProductN-(6-acetyl-3-methoxy-2-methylphenyl)-4-(trifluoromethyl)-1,3-thiazole-2-carboxamideHCID 5660515174%

Reaction Steps

Compound 64b was synthesized from 4-(trifluoromethyl)-1,3-thiazole-2-carboxylic acid and 1-(2-amino-4-methoxy-3-methylphenyl)-ethanone as a beige solid in 74% yield, following the procedure as described for compound 42a.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08093379B2
Source datasetuspto-grants-2012_01
ORD IDord-87d6329d760f4ab6a454e1a12d543bda
Source noteuspto-grants-2012_01