反应详情

To a stirred solution of compound 80 (230 mg, 0.92 mmol) in MeOH (5 mL) at 0° C. was added K2CO3 (255 mg, 1.84 mmol), and Ohira-Bestmann reagent (215 g, 1.10 mmol) (Tetr. Lett. 2008, 49, 4454). The mixture was stirred at room temperature for 16 hrs and was concentrated under reduced pressure. Water, EtOAc, and citric acid were added to bring pH to 4-5. Organics were dried over Na2SO4, filtered, and concentrated under reduced pressure to yield compound 81 in 85% yield.

1. concentrationwas concentrated under reduced pressure
2. additionWater, EtOAc, and citric acid were added
3. dry with materialOrganics were dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure