HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-Ethynylcyclopropane-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-Boc-1-ethynyl-cyclopropanesulfonic acid amide | HCID 57816689 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Ethynylcyclopropane-1-sulfonamide | HCID 57578732 | 70% |
Reaction Steps
A mixture of compound 81 (200 mg, 0.81 mmol) and TFA (0.3 mL) in DCM (5 mL) was stirred at room temperature for 16 hrs. The reaction mixture was concentrated under reduced pressure and the crude material was purified by chromatography on silica gel (MeOH/DCM) to yield compound 82 in 70% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093379B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-b1f34fdfd95b4beea33d28b680277221 |
| Source note | uspto-grants-2012_01 |