3-Methyl-2-butanone → HCID 53396467, compound

HRID 420064Notes

Reaction equation

[CH3:1][CH:2]([CH3:6])[C:3](=[O:5])[CH3:4].C(O[CH:10](OCC)[N:11]([CH3:13])[CH3:12])C>>[CH3:10][N:11]([CH3:13])[CH:12]=[CH:4][C:3](=[O:5])[CH:2]([CH3:6])[CH3:1]

Participants

Reactant 2

HCID 112513-Methyl-2-butanone

HCID 70913Dimethylformamide diethylacetal

Product 1

HCID 53396467HCID 53396467, compoundYield 80%

Procedure

3-Methylbutan-2-one (2.5 g, 1 eq.) and dimethylformamide diethylacetal (7.46 mL, 1.5 eq.) were heated at 100° C. for 4 days to give compound 85 as yellow viscous oil in 80% yield, which was used directly without further purification in the next step.

Sources & evidence

ORD record: ord-f2c4bbde019b4234930ba30059d8f0a6
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08093379B2

Reaction notes

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