HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester → (2S,4S)-1-tert-butyl 2-methyl 4-(8-chloro-7-methoxy-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)quinolin-4-yloxy)pyrrolidine-1,2-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester | HCID 2734883 | — |
| Reactant | Octadec-7-ene-4-carboxylic acid ethyl ester | HCID 86633208 | — |
| Reactant | HCID 178487711 | HCID 178487711 | — |
| Product | (2S,4S)-1-tert-butyl 2-methyl 4-(8-chloro-7-methoxy-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)quinolin-4-yloxy)pyrrolidine-1,2-dicarboxylate | HCID 66650753 | 90% |
Reaction Steps
Compound 112 was synthesized from N-Boc-trans-4-hydroxy-L-proline-methyl ester 111 and compound 88a as beige foam in 90% yield, following the procedure as described for compound 54c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093379B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-9328385e5c1c40de8a07a9e04ae15d50 |
| Source note | uspto-grants-2012_01 |