HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42011Generated: October 27, 2026
Toluene → 2-(Benzyloxy)-3-iodo-5-nitropyridine
https://huagongshe.com/reaction/42011
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | HCID 178526840 | HCID 178526840 | — |
| Solvent | Benzyl Bromide | HCID 7498 | — |
| Product | 2-(Benzyloxy)-3-iodo-5-nitropyridine | HCID 67394051 | 90% |
Reaction Steps
To a solution of 3-iodo-5-nitropyridin-2-ol (0.011 mol, 3 g) in 30 ml of toluene, 2.5 ml of (bromomethyl)benzene and 5.1 g of Ag2CO3 was added. The mixture was stirred at 70° C. for 6 h. The crude was filtered through Celite and washed with ethyl acetate. The solvent was evaporated affording 3.6 g (yield 90%) of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536165B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-57588fd7330a43c29c9e53395b7d8d3d |
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| Source note | uspto-grants-2013_09 |
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