反应详情

N-benzyl-O-methyl-D-serinamide (5 g), was mixed with DCM (25 ml) at ambient temperature and stirred for 10 minutes to get a clear solution. To this solution, dimethylaminopyridine (0.025 g) was added at ambient temperature. Acetic anhydride (2.695 g) was slowly added over 10-12 minutes at ambient temperature. The solution was stirred for 30 minutes at room temperature. The reaction mixture was washed with 5% sodium bicarbonate (15 ml) solution, deionized water (15 ml), and brine (10 ml). The layers were separated and solvent was completely recovered under vacuum at 35-40° C. to get crude product. Yield=5.9 gm.

1. customto get a clear solution
2. stirringThe solution was stirred for 30 minutes at room temperature
3. washThe reaction mixture was washed with 5% sodium bicarbonate (15 ml) solution
4. customThe layers were separated
5. customsolvent was completely recovered under vacuum at 35-40° C.
6. customto get crude product