1-Hydroxybenzotriazole → 6-(5-bromopyridin-3-yl)-1'-[(1-cyclopropyl-4-methoxy-3-methyl-1H-indol-6-yl)carbonyl]spiro[chroman-2,4'-piperidin]-4-one

HRID 420132Notes

Reaction equation

HRID 420132 reaction equation
[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:16][CH3:17])[CH:9]=[C:10]([C:13]([OH:15])=O)[CH:11]=3)[C:6]([CH3:18])=[CH:5]2)[CH2:3][CH2:2]1.Cl.Cl.[Br:21][C:22]1[CH:23]=[C:24]([C:28]2[CH:29]=[C:30]3[C:40](=[CH:41][CH:42]=2)[O:39][C:33]2([CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH2:32][C:31]3=[O:43])[CH:25]=[N:26][CH:27]=1.CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>C(OCC)(=O)C.CN(C=O)C.C(N(CC)CC)C>[Br:21][C:22]1[CH:23]=[C:24]([C:28]2[CH:29]=[C:30]3[C:40](=[CH:41][CH:42]=2)[O:39][C:33]2([CH2:34][CH2:35][N:36]([C:13]([C:10]4[CH:11]=[C:12]5[C:7]([C:6]([CH3:18])=[CH:5][N:4]5[CH:1]5[CH2:2][CH2:3]5)=[C:8]([O:16][CH3:17])[CH:9]=4)=[O:15])[CH2:37][CH2:38]2)[CH2:32][C:31]3=[O:43])[CH:25]=[N:26][CH:27]=1

Participants

8

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 569716581-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carboxylic acidHCID 666493846-(5-Bromo-3-pyridinyl)spiro-[chroman-2,4'-piperidin]-4-one dihydrochloride

Product 1

HCID 249668006-(5-bromopyridin-3-yl)-1'-[(1-cyclopropyl-4-methoxy-3-methyl-1H-indol-6-yl)carbonyl]spiro[chroman-2,4'-piperidin]-4-one

Reagents, catalysts & solvents 3

HCID 6228DimethylformamideSolventHCID 8471TriethylamineSolventHCID 8857Ethyl AcetateSolvent

Procedure

Triethylamine (0.33 mL) was added to a DMF (7.5 mL) solution of 1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carboxylic acid (147 mg), 6-(5-bromo-3-pyridinyl)spiro-[chroman-2,4′-piperidin]-4-one dihydrochloride (268 mg), WSC hydrochloride (164 mg) and HOBT (110 mg), and stirred at r.t. for 5 h. This reaction mixture was diluted with ethyl acetate, then washed with water, aqueous saturated sodium bicarbonate and saturated saline water in that order, and dried with sodium sulfate. This was filtered, concentrated, and purified through silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound as a colorless amorphous substance. 1H-NMR (400 MHz, DMSO-d6) δ: 8.86 (1H, d, J=2.0 Hz), 8.66 (1H, d, J=2.0 Hz), 8.36 (1H, t, J=2.0 Hz), 8.05-7.99 (2H, m), 7.24 (1H, d, J=8.6 Hz), 7.13 (1H, s), 7.00 (1H, s), 6.50 (1H, s), 4.40-4.08 (1H, br m), 3.83 (3H, s), 3.78-3.22 (4H, br m), 2.94 (2H, s), 2.31 (3H, s), 2.04-1.75 (4H, br m), 1.03-0.97 (2H, m), 0.89-0.84 (2H, m); MS [M+H]+=600, 602.

Workup

  1. washwashed with water, aqueous saturated sodium bicarbonate and saturated saline water in that order
  2. dry with materialdried with sodium sulfate
  3. filtrationThis was filtered
  4. concentrationconcentrated
  5. custompurified through silica gel column chromatography (hexane/ethyl acetate)

Sources & evidence

ORD record
ord-7333ecd556b34a4a942bb2c83a270d25
Source dataset
uspto-grants-2012_01
Patent number
US08093389B2

Reaction notes

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