HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420146Generated: October 30, 2026
Chlorosuccinimide → ethyl-3-chloro-1-cyclopropyl-4-(methoxy)-1H-indole-6-carboxylate
https://huagongshe.com/reaction/420146
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate | HCID 66649481 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | ethyl-3-chloro-1-cyclopropyl-4-(methoxy)-1H-indole-6-carboxylate | HCID 66649552 | 70.5% |
Reaction Steps
To a stirred solution of 1.29 g of ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate in 13 ml of THF was added 801 mg of N-chlorosuccinimide and the mixture was stirred at 60° C. for 2 hrs. After diluted with EtOAc, the mixture was washed successively with water and saturated brine, dried over Na2SO4, and concentrated. The residue was purified on SiO2 column chromatography to afford 1.03 g of ethyl-3-chloro-1-cyclopropyl-4-(methoxy)-1H-indole-6-carboxylate as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093389B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-df492794a6df4779bd733cdb7b24cbad |
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| Source note | uspto-grants-2012_01 |
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