HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420148Generated: October 29, 2026
Hydrochloric Acid → 1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carboxylic acid
https://huagongshe.com/reaction/420148
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 1-cyclopropyl-3-methyl-4-methoxy-1H-indole-6-carboxylate | HCID 66649525 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carboxylic acid | HCID 56971658 | 94.3% |
Reaction Steps
4.66 mL of 5 N NaOH aqueous was added to a solution of 3.19 g of ethyl 1-cyclopropyl-3-methyl-4-methoxy-1H-indole-6-carboxylate in 32 mL of MeOH and the mixture was stirred at 60° C. overnight. The mixture was cooled and 46.6 mL of 1N HCl was added thereto. The precipitate was filtered, collected and dried in vacuo to afford 2.70 g of 1-Cyclopropyl-3-methyl-4-methoxy-1H-indole-6-carboxylic acid as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093389B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-c14221621cd14b9f9dbaa03c7644f708 |
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| Source note | uspto-grants-2012_01 |
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