HCID 76650869, Verbindung → Tert-butyl 4-([tert-butyl(dimethyl)silyl]oxy)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-spiro[chroman-2,4'-piperidine]-1'-carboxylate

HRID 420155Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 420155
[NH2:1][C:2](=[N:33][O:34][C:35](OCC(CC)CCCC)=[O:36])[C:3]1[CH:4]=[C:5]2[C:22](=[CH:23][CH:24]=1)[O:21][C:8]1([CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]1)[CH2:7][CH:6]2[O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27]>C1(C)C(C)=CC=CC=1>[Si:26]([O:25][CH:6]1[C:5]2[C:22](=[CH:23][CH:24]=[C:3]([C:2]3[NH:1][C:35](=[O:36])[O:34][N:33]=3)[CH:4]=2)[O:21][C:8]2([CH2:9][CH2:10][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:18])[CH3:19])=[O:15])[CH2:12][CH2:13]2)[CH2:7]1)([C:29]([CH3:30])([CH3:32])[CH3:31])([CH3:28])[CH3:27]

Komponenten

3

Edukt 1

HCID 76650869HCID 76650869, Verbindung

Produkt 1

HCID 136136848Tert-butyl 4-([tert-butyl(dimethyl)silyl]oxy)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-spiro[chroman-2,4'-piperidine]-1'-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

A solution of tert-butyl 6-{amino[({[(2-ethylhexyl)oxy]carbonyl}oxy)imino]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}spiro[chroman-2,4′-piperidine]-1′-carboxylate in 100 mL of xylene was stirred at 145° C. for 14 h. The reaction mixture was cooled to r.t., and concentrated in reduced pressure. The residue was purified by column chromatography on silica gel using a mixture of hexane-AcOEt (100/1-35/65) as an eluent to give the product as an off-white solid.

Aufarbeitung

  1. concentrationconcentrated in reduced pressure
  2. customThe residue was purified by column chromatography on silica gel using
  3. additiona mixture of hexane-AcOEt (100/1-35/65) as an eluent

Quellen und Nachweise

ORD-Eintrag
ord-2988777a87664f01ae21efc1e2479711
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093389B2

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