1-Acetoxy-2-bromoethane → Ethyl 1-cyclopropyl-4-(2-hydroxyethoxy)-1H-indole-6-carboxylate

HRID 420168Notes

Reaction equation

HRID 420168 reaction equation
[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:18][CH3:19])[CH:9]=[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:11]=3)[CH:6]=[CH:5]2)[CH2:3][CH2:2]1.[C:20](OCCBr)(=[O:22])C>>[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:18][CH2:19][CH2:20][OH:22])[CH:9]=[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:11]=3)[CH:6]=[CH:5]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 135641-Acetoxy-2-bromoethaneHCID 66649481ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate

Product 1

HCID 66649692Ethyl 1-cyclopropyl-4-(2-hydroxyethoxy)-1H-indole-6-carboxylate

Procedure

The compound was prepared according to the procedure for ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate but using bromoethyl acetate in place of MeI.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e67bbd333ba341009d64675bd5d229aa
Source dataset
uspto-grants-2012_01
Patent number
US08093389B2

Reaction notes

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