2,5-Dibromopyridine → 2-(5-Bromopyridin-2-yl)pyrazine

HRID 42023Notes

Reaction equation

HRID 42023 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.C([Sn](CCCC)(CCCC)[C:14]1[CH:19]=[N:18][CH:17]=[CH:16][N:15]=1)CCC>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([C:14]2[CH:19]=[N:18][CH:17]=[CH:16][N:15]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 693532,5-DibromopyridineHCID 27373162-(Tributylstannyl)pyrazine

Product 1

HCID 584157932-(5-Bromopyridin-2-yl)pyrazineYield 60%

Procedure

Obtained (0.310 g, yield 60%) following the procedure described in Intermediate 37, starting with 2,5-dibromopyridine (2.11 mmol, 0.5 g), 2-(tributylstannyl)pyrazine (2.32 mmol, 0.857 g).

Workup

  1. customObtained (0.310 g, yield 60%)

Sources & evidence

ORD record
ord-2e5cddc48e624af991d0c4d260bc7e29
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

Loading…