Triphenylphosphine → HCID 131729366, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (3aR*,7S*,7aS*)-7-(4-amino-3-fluoro-5-vinyl-benzyl)-3-(3-tert-butyl-benzyl)-5,5-dioxo-hexahydro-1-oxa-5lambda*6*-thia-3-aza-inden-2-one (0.215 g, 0.44 mmol) in CH2Cl2-MeOH 4:1 (10 mL) was ozonized at −78° C. until the educt disappeared. After addition of PPh3 (0.139 g, 0.53 mmol) the reaction mixture was allowed to warm to 25° C. and the solvents were removed under reduced pressure. The title compound was obtained after flash-chromatography on silica gel (hexane-EtOAc 2:1) as white solid: ESIMS [M−H]−=487.

Provenance & Evidence