2-Azetidinone → HCID 44624303, compound

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Reaction Steps

The title compound was prepared in analogous manner as described for example 4 from (3aR*,7S*,7aS*)-7-(4-amino-3-fluoro-5-iodo-benzyl)-3-(3-tert-butyl-benzyl)-5,5-dioxo-hexa-hydro-1-oxa-5lambda*6*-thia-3-aza-inden-2-one (example 1k) and azetidin-2-one: HPLC RtC=2.99 min; ESIMS [M+H]+=504; NMR (400 MHz, CDCl3+0.5% D2O): δ 7.65 (m, 2H), 7.56 (t, 1H), 7.47 (m, 3H), 6.30 (m, 2H), 4.20 (q, 2H), 3.80 (m, 2H), 3.59 (m, 2H), 3.35, (m, 2H), 3.18 (m, 2H), 2.95 (m, 1H), 2.85 (m, 1H), 2.75 (m, 2H), 1.30 (s, 9H).

Provenance & Evidence