HCID 68556009, compound → HCID 44624305, compound

Participants

Reaction Steps

The title compound was prepared in analogous manner as described for example 1o) from (3aR*,7S*,7aS*)-3-(3-tert-butyl-benzyl)-7-[4-(2-dimethylamino-ethylamino)-3-fluoro-benzyl]-5,5-dioxo-hexahydro-1-oxa-5lambda*6*-thia-3-aza-inden-2-one to yield a sticky oil: TLC (toluene-ETA 85:15) Rf=0.20; HPLC RtA=1.51 min; ESIMS [M+H]+=506; 1H-NMR (600 MHz, DMSO-d6): δ 7.35 (s, 1H), 7.24 (m, 2H), 7.13 (d, 1H), 6.85 (d, 1H), 6.78 (d, 1H), 6.65 (t, 1H), 5.65 (d, 1H), 4.92 (m, 1H), 3.80 (d, 1H), 3.62 (d, 1H), 3.37 (m, 1H), 3.10 (m, 3H), 2.95 (m, 3H), 2.78 (m, 1H), 2.63 (m, 1H), 2.45 (t, 2H), 2.37 (m, 1H), 2.15 (s, 6H), 1.98 (m, 1H), 1.25 (s, 9H).

Provenance & Evidence