HCID 66649526, compound → HCID 131729369, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3aR,5S,7S,7aS)-7-(4-benzyloxycarbonylamino-3-fluoro-benzyl)-2,2-dimethyl-5-oxo-hexahydro-1-oxa-5lambda*4*-thia-3-aza-indene-3-carboxylic acid tert-butyl ester (11.0 g, 20.1 mmol) in CH2Cl2 (80 mL) was slowly added under cooling TFA (15.5 mL, 201 mmol) and the reaction mixture was stirred for 3 h at 25° C. The reaction mixture was evaporated to dryness and the dried residue was titurated with diisopropylether. The title compound was obtained after filtration and drying as a light yellow solid: UPLC RtD=1.077 min; RtE=0.990 min; ESIMS [M+H]+=407; 1H NMR (400 MHz, CD3OD): δ 7.76 (m, 1H), 7.35 (m, 5H), 7.05 (m, 2H), 5.19 (s, 2H), 3.64 (dt, 1H), 3.41 (t, 1H), 3.34 (m, 1H), 3.25 (m, 2H), 2.82 (t, 1H), 2.57 (m, 2H), 2.01 (m, 1H).

Provenance & Evidence