HCID 131729370, compound → HCID 66649435, compound

Participants

Reaction Steps

A solution of {4-[(3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-2,5,5-trioxo-octahydro-1-oxa-5lambda*6*-thia-3-aza-inden-7-ylmethyl]-2-fluoro-phenyl}-carbamic acid benzyl ester (9.6 g, 15.8 mmol) in THF-MeOH 1:2 (150 mL) was hydrogenated over 10% Pd/C (0.7 g) for 4 h at 45° C. and 1 bar. The catalyst was filtered off over Celite and the filtrate is evaporated to provide the title compound as a colorless solid: TLC (toluene-EtOAc 3:1) Rf=0.26; UPLC RtD=1.596 min; ESIMS [M+NH4]+=478; 1H NMR (600 MHz, DMSO-d6): δ 7.38 (s, 1H), 7.32 (d, 1H), 7.27 (t, 1H), 7.13 (d, 1H), 6.83 (d, 1H), 6.69 (m, 2H), 5.02 (s, 2H), 4.42 (d, 1H), 4.22 (d, 1H), 4.11 (t, 1H), 3.67 (m, 2H), 3.46 (t, 1H), 3.01 (m, 2H), 2.79 (dd, 1H), 2.44 (m, 2H), 1.26 (s, 9H).

Provenance & Evidence