Methoxyacetyl chloride → HCID 131729374, compound

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Reaction Steps

The title compound was prepared in analogous manner as described for example 8q and 8r from N-{4-[(3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-2,5,5-trioxo-octahydro-1-oxa-5lambda*6*-thia-3-aza-inden-7-ylmethyl]-2-ethyl-6-fluoro-phenyl}-2-chloro-acetamide and methoxy-acetyl chloride to yield after preparative HPLC purification (Sunfire C18 OBD 5 μm, 100×30, 5-100% ACN in water+0.1% TFA gradient, 25 min) the title compound as a light yellow amorphous solid: TLC (EtOAc-MeOH 9:1) Rf=0.56; UPLC RtD=1.298 min; ESIMS [M+H]+=535; 1H NMR (600 MHz, DMSO-d6): δ 9.99 (s, 1H), 9.31 (s, 1H), 9.08 (s, 1H), 7.68 (s, 1H), 7.44 (dd, 1H), 7.39 (m, 3H), 6.96 (d, 1H), 6.92 (s, 1H), 6.23 (s, 1H), 4.23 (m, 4H), 4.01 (s, 2H), 3.91 (d, 1H), 3.66 (m, 2H), 3.38 (s, 3H), 3.26 (dd, 1H), 3.17 (m, 2H), 2.76 (dd, 1H), 2.52 (m, 3H), 2.10 (m, 1H), 1.29 (s, 9H), 1.08 (t, 3H).

Provenance & Evidence