HCID 66649651, compound → HCID 66649644, compound

Participants

Reaction Steps

The title compound was prepared in analogous manner as described for example 1j) from (3aR,7S,7aS)-3-(3-tert-butyl-benzyl)-7-[3-fluoro-4-nitro-5-(2,2,2-trifluoro-ethoxy)-benzyl]-5,5-dioxo-hexahydro-1-oxa-5lambda*6*-thia-3-aza-inden-2-one (1.32 g, 2.24 mmol) to yield a white foam: TLC Rf=0.60 (toluene-ETA 85:15); ESIMS [M+NH4]+=576; LCMS RtH1=3.60 min API ESI pos. [M+H]+=559; 1H NMR (600 MHz, DMSO-d6): δ 7.39 (s, 1H), 7.32 (d, 1H), 7.28 (t, 1H), 7.10 (d, 1H), 6.66 (s, 1H), 6.65 (d, 1H), 4.70 (q, 2H), 4.60 (s, 2H), 4.41 (d, 1H), 4.20 (d, 1H), 4.14 (t, 1H), 3.73 (m, 1H), 3.63 (m, 1H), 3.45 (t, 1H), 3.05 (m, 1H), 2.97 (m, 1H), 2.80 (m, 1H), 2.41 (m, 2H), 1.25 (s, 9H).

Provenance & Evidence