HCID 66649701, compound → HCID 66649683, compound

Participants

Reaction Steps

The title compound was prepared in an analogous manner as described for example 41d) from (1S,3R,4S,5S)-3-(3-tert-butyl-benzylamino)-5-[3-fluoro-4-nitro-5-((R)-2,2,2-trifluoro-1-methoxymethyl-ethoxy)-benzyl]-1-oxo-tetrahydro-thiopyran-4-ol as an amorphous solid: TLC (EtOAc-MeOH 9:1) Rf=0.48; HPLC RtH1=0.91 min; ESIMS [M+H]+=561; 1H NMR (600 MHz, CDCl3): δ 7.36 (s, 1H), 7.24 (m, 2H), 7.13 (d, 1H), 6.74 (s, 1H), 6.65 (d, 1H), 5.15 (s, 1H), 5.06 (s, 1H), 4.58 (s, 2H), 3.83-3.79 (m, 2H), 3.73 (m, 2H), 3.63 (dd, 1H), 3.53 (d, 1H), 3.30 (s, 3H), 3.03 (m, 1H), 2.97 (m, 2H), 2.49-2.32 (m, 4H), 1.70-2.62 (m, 1H), 1.25 (s, 9H).

Provenance & Evidence